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Originally Posted by Frequency  Indeed, perhaps over a long time of SSRI exposure, but it is the occupation of the reuptake transporters and receptors that is responsible for diminishing the action of most serotonergic psychedelics. Take fluoxetine for instance. It has a higher affinity for the SRT's (serotonin reuptake transporters) and serotonergic receptors than both serotonin and other tryptamine/phenethyalmine alkaloids. Therefore if one were to take a dose of fluoxetine prior to a psychedelic substance they would have little effect because the fluoxetine was in the way. It's already chilling in the receptors effectively blocking any other chemicals with similar affinity.
The long-term use of said SSRI's will, as Lysergic pointed out, eventually lead to down-regulation of the serotonergic system effectively damanging it temporarily up until years after cessastion. As Lys also pointed out, it's the MAOI's you'd have to worry about. If you use substances that would normally be broken down in a timely mannor by your own endogenous monoamine oxidase enzymes while using an MAO inhibitor than you're risking depleting your natural serotonin supply temporarily (not damaging per se) which leaves dopamine to freely bind to your serotonergic receptors. In the absence of 5HT (serotonin) all of the excess DA (dopamine, which has a higher affinity for the serotonergic receptors than serotonin or fluoxetine) gets eventually reuptaken by the SRT's and oxidized into Hydrogen Peroxide. Not the best substance to occupy your brain with. This only happens when serotonin is depleted from the synapse. It normally doesn't happen but when you inhibit your MAO long enough, you'll run out of serotonin and that will leave your DA freely available to bind, be reuptaken, and then broken down into H2O2. That H2O2 accelerates the natural oxidation your brain cells go through every day to the point of degradation, damage, and disability.
That's the real danger. |
Thanks dude
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Originally Posted by Hippie3 so, doctor, your prescription is for me
to have a drink, smoke a doob and scarf chocolate ?
that i can do,,,  |
That would be one bourbon, one scotch, and one beer
In addition to smoking two joints before you smoke two joints.
And don't forget to call me in the morning!
