Marijuana May Help To Fight Inflammation And Allergies

[Glasshopper]

This was taken from here on Science Daily.

Some good info if you live in an area with legal medical marijuana.

Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies

Science Daily — Endocannabinoids seem to play an important role in regulating inflammation processes. Scientists from the University of Bonn have discovered this in experiments on mice. Their results will be published in the journal 'Science' on 8 June. The study may also have implications for therapy. In animal experiments, a solution with an important component made from cannabis reduced allergic reactions of the skin

Extracts of the hemp plant cannabis are traditionally used as a popular remedy against inflammation. At the beginning of the last century this natural remedy was even available at every chemist's. But due to the intoxicating effect of the component THC (tetrahydrocannabinol) the plant was taken off the chemist's shelves in the 1930s.


THC acts on the cannabinoid receptors, of which there are two types, CB1 and CB2. Both receptors are made such that THC can attach itself to them. In the brain this causes the intoxicating effect of hashish, cannabis and marijuana. But why does the body have CB1 and CB2 anyway" For two decades it has been known that the human body also produces its own cannabinoids. Like THC they can attach themselves to the receptors. The brain scientist Professor Andreas Zimmer from the Bonn Institute of Molecular Psychiatry is investigating what the function of this endocannabinoid system is. 'Mice without CB1 receptors show psychological abnormalities,' he explains. 'By contrast, CB2 regulates the growth of bones, for example.'



Coincidence
However, according to these most recent results, endocannabinoids also seem to play an important part in regulating inflammation processes. As is often the case with important discoveries, coincidence was involved. In scientific experiments mice are given an ear clip, so that researchers can tell them apart.' In most cases the mice can handle this without problems,' Dr. Meliha Karsak, a member of Professor Zimmer's team, explains. 'With our mice this was different. The skin around the ear clips became inflamed.' There are genetically modified strains of mice in which both cannabinoid receptors are dysfunctional.' And it was in precisely these strains that the inflammation occurred,' she explains.


Together with the Bonn dermatologists Dr. Evelyn Gaffal and Professor Thomas Tüting the researchers investigated these findings. Skin rash can be caused by allergens in laboratory mice. 'However, normally these rashes are only minor,' Dr. Gaffal emphasises. 'However, strains of mice in which the cannabinoid receptors are missing react much more intensely. We observed something similar when we blocked the receptors with medication.'

Step on the brakes
When inflammation occurs the endocannabinoids act like someone stepping on the brakes. They prevent the body from doing too much of a good thing and the immune reaction from getting out of control. This is consistent with the fact that at the beginning of the infection the endocannabinoid concentration increased in the mice. 'Apart from that there are strains of mice in which the breakdown of these active substances produced by the body is malfunction-ing,' Evelyn Gaffal says. 'They have an increased endocannabinoid concen-tration in their skin. In our experiments these animals also showed a less marked allergic reaction.'


The results open up new options for the treatment of skin allergies and inflammation. Firstly, drugs which prevent the breakdown of endocannabin-oids look promising. But the old household remedy cannabis could also make a comeback as an ointment. In the experiment on mice this approach has already been successful. 'If we dabbed THC solution on to the animals' skin shortly before and after applying the allergen, a lot less swelling occurred than normal,' Professor Thomas Tüting explains. 'THC attaches itself to cannabin-oid receptors and activates them. In this way the active substance reduces the allergic reaction.' Incidentally, ointment like this would probably not have an intoxicating effect, for this the amount of THC contained would be much too small.


Note: This story has been adapted from a news release issued by University of Bonn

[Invalid Comfort]

I haven't ever heard of the endocanniboid(sp?) before. This is an incredibly interesting topic.

I wonder if our race has been smoking ganja for so long that our bodies adopted the obvious benefits. This is a hella interesting way to evolve, wonder where the humans will be in 500 yrs.

I understand the anti-inflamatory, but it tends to have the opposite effect on my sinuses. Heh, I'm a living example of the darwinian dis-advantage .

[Defiance]

Originally Posted by Invalid Comfort

I wonder if our race has been smoking ganja for so long that our bodies adopted the obvious benefits. This is a hella interesting way to evolve, wonder where the humans will be in 500 yrs.

Probably still on the couch, but the pizza and video games will be way better.

[dizzydank]

allergies aye?i got bad ass allergies and smoke alot of pot. i dont believe pot does anything for allergies. mine are just as bad as when i didnt smoke.

[Hippie3]

agreed.
i've heavily smoked pot daily for 35 years
and i still have inflammation, take meds for it.

guess i'll keep trying though.